Clinical Trials

Our patients have access to the latest advances in liver disease care and to clinical trials investigating the therapies of tomorrow


The Liver Specialty Center team works closely with other world-class specialists in imaging, pathology, surgery and oncology to provide our patients comprehensive care of their liver disease


We treat thousands of patients every year from throughout California, the United States and the world. The Liver Specialty Center physicians are recognized experts in all types of liver disease.

Liver Disease Care

The Liver Specialty Center is located in the Spectrum Medical Plaza Suite 106 at 15825 Laguna Canyon Rd. We are conveniently located at the corner of Laguna Canyon Road and Waterworks.

The Liver Specialty Center specializes in hepatology, the study and treatment of liver disease, and liver related problems such as ascites, variceal bleeding, hepatic encephalopathy and primary liver cancer (hepatocellular carcinoma HCC).

Dr Hoefs has been a hepatologist in Orange County for 30 years as Director of the Liver Disease Program at the University of California Irvine. He now seeks to employ his skills in the management of liver patients outside of UCI. The cause of liver disease determines the treatment so diagnosis is essential for hepatitis B (HBV), hepatitis C (HCV), non-alcoholic fatty liver disease (NAFLD), non-alcoholic hepatitis (NASH), primary biliary cirrhosis (PBC), autoimmune chronic active hepatitis (ACAH), primary sclerosing cholangitis (PSC), hemachromatosis (and other forms of iron overload) and numerous other less common liver diseases. Some patients have more than one cause.

We particularly emphasize the treatment of chronic hepatitis C since we can cure 70 % of patients, and with new antiviral agents.

Optimize Your Liver

Dr. Hoefs is currently accepting new patients. Visit the new patient corner to download forms you may need for your visit or call or email us at the contact listed at the top of this page. We want to help you into optimal liver health.


Current patients, we want to help you maintain your optimal liver health. If you have any questions please do not hesitate to call. If you are due for an appointment give our office a call or email. If you need copies of educational material provided by our office please go to the patient portal.


Referring physicians are our partners in helping our patients achieve optimal liver health. To refer a patient click here. To view Dr. Hoefs credentials and publications please follow the links above. To contact Dr. Hoefs directly please email his nurse at the link above and he will get back to you within 48 hours.


16305 Sand Canyon Ave
Suite 220 
Irvine CA 92618
Phone: 949.748.7474
Fax: 949.272.5858
Monday - Friday open 8:00 - 4:00

Our Services

  • Specialized treatment in hepatitis C
  • Specialized treatment in hepatitis B
  • Paracentesis
  • Liver biopsy
  • Liver spleen scan
  • Liver specific lab testing
  • Vaccinations for hepatitis A & B